Ephraim (; Hebrew: אֶפְרַיִם‎ ʾEp̄rayīm, in pausa: אֶפְרָיִם‎ ʾEp̄rāyīm) was, according to the Book of Genesis, the second son of Joseph ben Jacob and Asenath. Asenath was an Ancient Egyptian woman whom Pharaoh gave to Joseph as wife, and the daughter of Potipherah, a priest of ʾĀwen. Ephraim was born in Egypt before the arrival of the Israelites from Canaan.

The Book of Numbers lists three sons of Ephraim: Shuthelah, Beker, and Tahan. However, 1 Chronicles 7 lists eight sons, including Ezer and Elead, who were killed in an attempt to steal cattle from the locals. After their deaths he had another son, Beriah. He was the ancestor of Joshua, son of Nun ben Elishama, the leader of the Israelite tribes in the conquest of Canaan.

According to the biblical narrative, Jeroboam, who became the first king of the Northern Kingdom of Israel, was also from the house of Ephraim.